The Science Hub
Six pathways. Every paper. No hand-waving.
Every blend in our catalog is built around the cellular mechanisms longevity research keeps converging on. Pick a pathway to read the full deep-dive, or start with the latest research notes below.
Browse by pathway
PATHWAY 01
AMPK
When AMPK rises, the body shifts from storage to repair.
PATHWAY 02
mTOR
Anabolism on demand. Inhibition on a schedule.
PATHWAY 03
SIRT1
DNA repair, mitochondrial biogenesis, and metabolic flexibility — all downstream of one enzyme.
PATHWAY 04
NRF2
Don't supplement antioxidants. Activate your own.
PATHWAY 05
Autophagy
The cell's recycling program. Skip a meal, and it turns on.
PATHWAY 06
NAD+
Every sirtuin runs on it. Levels fall ~50% by your fifties.
Research notes
From the journals, in plain English.
Berberine vs. Metformin: what the head-to-head trials actually show
Three randomized trials have now compared berberine head-to-head with metformin in type 2 diabetics. The headline result: equivalent HbA1c reduction, with berberine producing modestly better lipid outcomes.
Sulforaphane doesn't fight free radicals. It teaches your body to.
The right way to fight oxidative stress isn't to swallow more antioxidants. It's to turn on the genes that make your own. Sulforaphane is the most potent dietary lever we know of.
Spermidine: the only known dietary compound that triggers autophagy without fasting
Autophagy is one of the most replicable interventions in lifespan research. Until recently the only proven trigger was caloric restriction. Spermidine changed that.
NMN vs. NR: a precursor-by-precursor comparison
Nicotinamide mononucleotide and nicotinamide riboside both raise circulating NAD+ in humans. The differences live in bioavailability, cost-per-effective-dose, and tissue distribution.
The intermittent fasting protocol we actually recommend
Most people fast wrong. Either too aggressively (and quit) or too gently (and never trigger the mechanisms that matter). This is the schedule that works.
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